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- Hereditary persistence of fetal hemoglobin - PMC
Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced
- Hereditary persistence of fetal hemoglobin - Wikipedia
HPFH can be caused by mutations in the β globin gene cluster, or the γ gene promoter region [1] In addition HbF levels are influenced by polymorphisms in the BCL11A gene [3] and in the MYB gene enhancer [4] In HPFH the percentage of HbF varies from 0 8-1 0% to about 30% of the total hemoglobin, but levels as high as 100% can be seen in homozygotes for delta beta thalassemia
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- Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF . . . - MDPI
Elevated fetal hemoglobin (HbF), which is partly controlled by genetic modifiers, ameliorates disease severity in β hemoglobinopathies Understanding the genetic basis of this trait holds great promise for personalized therapeutic approaches PubMed, MedRxiv, and the GWAS Catalog were searched up to May 2024 to identify eligible GWAS studies following PRISMA guidelines Four independent
- Switching from fetal to adult hemoglobin - Nature Genetics
In healthy humans, a shift from γ-globin to β-globin gene expression around birth underlies the switch from fetal (α 2 γ 2; HbF) to adult (α 2 β 2; HbA) hemoglobin production, such that by 6
- Fetal Hemoglobin - an overview | ScienceDirect Topics
4 1 Fetal Hemoglobin Fetal hemoglobin binds to oxygen more strongly than adult hemoglobin, enabling the transfer of oxygen from mother to fetus prenatally Oxygen exchange within the tissue is thus affected by the strength of the binding between hemoglobin and oxygen Human infants continue to generate significant amounts of fetal hemoglobin for up to 6 months postnatally (Thein et al , 2009
- HPFH - Overview: Hemoglobin F Distribution, Blood
Distinguishing large deletional hereditary persistence of fetal hemoglobin from other conditions with increased percentage of fetal hemoglobin (Hb F) Determining the distribution of Hb F within red blood cells
- Interpreting elevated fetal hemoglobin in pathology and health at the . . .
Introduction Fetal hemoglobin (HbF) is the high oxygen affinity tetramer that can transfer oxygen from the maternal to the fetal circulation While predominant in the fetus from about 10 weeks of gestation until birth, in normal conditions only traces of HbF (<1%) are present in postnatal life after the age of 1 year
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