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- Caveolins and intracellular calcium regulation in human airway smooth . . .
Regulation of intracellular Ca (2+) concentration ( [Ca (2+)] (i)) is a key factor in airway smooth muscle (ASM) tone In vascular smooth muscle, specialized membrane microdomains (caveolae) expressing the scaffolding protein caveolin-1 are thought to facilitate cellular signal transduction
- Caveolin-3 differentially orchestrates cholinergic and serotonergic . . .
Ultrastructure of caveolae in airway smooth muscle from cav-3 + + and cav-3 − − mice Representative images for tracheae of cav-3 + + mice (WT, n = 4 animals) and cav-3 − − (KO, n = 6
- Role of Caveolae in the Airway - Springer
In smooth muscle cells, including those of the airway, caveolae contain proteins that regulate intracellular Ca 2+ ( [Ca 2+] i) and contractility, as well as cellular proliferation [28 – 31]
- Caveolin-1 and -2 in airway epithelium: expression and in situ . . .
Fluorescence immunohistochemistry was performed to locate caveolae and cav-1 and -2 in the airway epithelium of rats, mice and humans Electron-microscopic analysis was used for the identification of caveolae CLSM-FRET analysis determined the interaction of cav-1α and cav-2 in situ
- Caveolin‐1 regulates intracellular Ca2+ in human airway smooth muscle . . .
Intracellular calcium ( [Ca 2+] i) in airway smooth muscle (ASM) is key to contractility In vascular smooth muscle, specialized plasma membrane microdomains (caveolae) expressing the scaffolding protein caveolin are thought to facilitate signal transduction
- Caveolin-1 knockout mice exhibit airway hyperreactivity
We and others have previously shown that caveolae of human airway smooth muscle (ASM), which express caveolin-1, contain Ca (2+) and force regulatory proteins and are involved in mediating the effects of inflammatory cytokines such as TNF-α on intracellular Ca (2+) concentration responses to agonist
- Caveolin-1 in cytokine-induced enhancement of intracellular Ca (2+) in . . .
Enhanced airway smooth muscle (ASM) intracellular Ca (2+) ( [Ca (2+)] (i)) response to agonist stimulation leading to increased airway constriction has been suggested to contribute to airway hyperresponsiveness
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